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SNPs ( p <5×10 −5 ) associated with in vitro HIV-1 replication in monocyte-derived macrophages.
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SNPs ( p <5×10 −5 ) associated with in vitro HIV-1 replication in monocyte-derived macrophages.
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SNPs ( p <5×10 −5 ) associated with in vitro HIV-1 replication in monocyte-derived macrophages.
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SNPs ( p <5×10 −5 ) associated with in vitro HIV-1 replication in monocyte-derived macrophages.
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SNPs ( p <5×10 −5 ) associated with in vitro HIV-1 replication in monocyte-derived macrophages.
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Image Search Results


SNPs ( p <5×10 −5 ) associated with in vitro HIV-1 replication in monocyte-derived macrophages.

Journal: PLoS ONE

Article Title: Genome-Wide Association Study Identifies Single Nucleotide Polymorphism in DYRK1A Associated with Replication of HIV-1 in Monocyte-Derived Macrophages

doi: 10.1371/journal.pone.0017190

Figure Lengend Snippet: SNPs ( p <5×10 −5 ) associated with in vitro HIV-1 replication in monocyte-derived macrophages.

Article Snippet: ABI TaqMan® SNP genotyping assays were used to genotype DNA from the replication cohort for rs12483205 (C_31609775_10), rs12909130 (C_1342209_10) as a proxy for rs2304418, rs2905 (C_3236245_20), rs1046099 (C_7585751_10) and rs17519417 (C_33238869_10) (Applied Biosystems, Carlsbad, CA, USA).

Techniques: In Vitro

The negative association between the rs12483205 minor allele and Gag p24 levels in MDM culture supernatant 14 days after inoculation with HIV-1, was found to match with the results from the genome-wide association study. Open circles represent results from donors with the CCR5 Δ32 wild-type genotype, filled circles from donors with the CCR5 wt/ Δ32 heterozygous genotype. MAJ, homozygous for the major allele; HZ, heterozygote; MIN, homozygous for the minor allele.

Journal: PLoS ONE

Article Title: Genome-Wide Association Study Identifies Single Nucleotide Polymorphism in DYRK1A Associated with Replication of HIV-1 in Monocyte-Derived Macrophages

doi: 10.1371/journal.pone.0017190

Figure Lengend Snippet: The negative association between the rs12483205 minor allele and Gag p24 levels in MDM culture supernatant 14 days after inoculation with HIV-1, was found to match with the results from the genome-wide association study. Open circles represent results from donors with the CCR5 Δ32 wild-type genotype, filled circles from donors with the CCR5 wt/ Δ32 heterozygous genotype. MAJ, homozygous for the major allele; HZ, heterozygote; MIN, homozygous for the minor allele.

Article Snippet: ABI TaqMan® SNP genotyping assays were used to genotype DNA from the replication cohort for rs12483205 (C_31609775_10), rs12909130 (C_1342209_10) as a proxy for rs2304418, rs2905 (C_3236245_20), rs1046099 (C_7585751_10) and rs17519417 (C_33238869_10) (Applied Biosystems, Carlsbad, CA, USA).

Techniques: GWAS

Results ( p values) for association testing using the additive analysis model, between disease progression or viral load and the SNPs in DYRK1A , PDE8A , UBR7 , MOAP1 and SPOCK3 .

Journal: PLoS ONE

Article Title: Genome-Wide Association Study Identifies Single Nucleotide Polymorphism in DYRK1A Associated with Replication of HIV-1 in Monocyte-Derived Macrophages

doi: 10.1371/journal.pone.0017190

Figure Lengend Snippet: Results ( p values) for association testing using the additive analysis model, between disease progression or viral load and the SNPs in DYRK1A , PDE8A , UBR7 , MOAP1 and SPOCK3 .

Article Snippet: ABI TaqMan® SNP genotyping assays were used to genotype DNA from the replication cohort for rs12483205 (C_31609775_10), rs12909130 (C_1342209_10) as a proxy for rs2304418, rs2905 (C_3236245_20), rs1046099 (C_7585751_10) and rs17519417 (C_33238869_10) (Applied Biosystems, Carlsbad, CA, USA).

Techniques: Biomarker Discovery

Untranslated regions (UTR) are shown as open blocks, whereas exons are shown as filled blocks. SNP rs12483205 lies in close proximity to a part of the 5′ UTR unique for splice variant 3.

Journal: PLoS ONE

Article Title: Genome-Wide Association Study Identifies Single Nucleotide Polymorphism in DYRK1A Associated with Replication of HIV-1 in Monocyte-Derived Macrophages

doi: 10.1371/journal.pone.0017190

Figure Lengend Snippet: Untranslated regions (UTR) are shown as open blocks, whereas exons are shown as filled blocks. SNP rs12483205 lies in close proximity to a part of the 5′ UTR unique for splice variant 3.

Article Snippet: ABI TaqMan® SNP genotyping assays were used to genotype DNA from the replication cohort for rs12483205 (C_31609775_10), rs12909130 (C_1342209_10) as a proxy for rs2304418, rs2905 (C_3236245_20), rs1046099 (C_7585751_10) and rs17519417 (C_33238869_10) (Applied Biosystems, Carlsbad, CA, USA).

Techniques: Variant Assay